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pESAC13??

Bio S?T???????pESAC13?????????pESAC13 PAC????????????????NAICONS??????????????????Streptomyces sp.??????Actinomycete sp.????????DNA?????????????????????????????????????

ESAC (E. coli-Streptomyces Artificial Chromosome) ??????????????????????????????????????????????????????????????

pESAC13?pPAC-S1??????????????ESAC?? ?Sosio et al., 2000?????????RK2????Simon et al., 1983??oriT?760bp DNA?????pPAC-S1?M. Sosio et al., unpublished??BstXI??????????

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BAC cloning and heterologous expression of a giant biosynthetic gene cluster encoding antifungal neotetrafibricin in streptomyces rubrisoli.

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Streptomyces BAC Cloning of a Large-Sized Biosynthetic Gene Cluster of NPP B1, a Potential SARS-CoV-2 RdRp Inhibitor

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