逆转录病毒研究

Bio S&T is the only commercial provider of highly purified human tRNAs.

RNA is most widely used as the primer of retroviral reverse transcriptases. The 3’ end of the tRNA binds to the complementary binding site on the viral RNA therefore initiating reverse transcription.

1. tRNALys3 is the primer of HIV-I, HIV-II, SIV and FIV.
2. tRNALys1,2 are the primers of BLV, HTLV-I and II, SSV, FLV, VV, CAEV, MPMV, SMR and EIAV.
3. tRNATrp and tRNAPro are the primers of ASNV, SSV, FLV, BLV, MLV, HTLV-I and II.

Since it has been well documented that artificial tRNA does not posses the same biological properties as natural tRNA, human purified tRNAs are largely in demand for retroviral research, especially HIV related research.

The extraction and purification of tRNA from a natural source such as human placenta is a highly complex and delicate procedure.

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